2. Signaling Pathways
  3. PROTAC
  4. Ligands for Target Protein for PROTAC

Ligands for Target Protein for PROTAC

Target Protein-binding Moiety

Ligands for Target Protein for PROTAC

Related Products

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The PROTAC molecule consists of a target protein ligand and an E3 ubiquitin ligase ligand, with a linker binds them together. The ligand for target protein will lead to attachment of a PROTAC to the proteins of interest for ubiquitin and subsequent degradation.

Target proteins are usually proteins whose overexpression or accumulation may play important roles in the progress of diseases. Numbers of PROTACs have been developed to degrade kinases (such as MEK, KRAS, CDK and Bcr/Abl), transcription factors (such as p53, STAT, RAR, ER and AR), epigenetic tools (such as HDAC and BET bromodomain) and E3 ligase themselves (such as MDM2).

Ligands for Target Protein for PROTAC Related Products (510):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-183071
    CDK7 ligand 3 3040999-61-6
    CDK7 ligand 3 is a target protein ligand for CXJ2080 (HY-183070), which be used for the research of acute leukemia.
    CDK7 ligand 3
  • HY-163610
    AKR1C3-IN-13
    AKR1C3-IN-13 (Compound 4) is an AKR1C3 inhibitor. AKR1C3-IN-13 degrades AKR1C3 in prostate cancer cells.
    AKR1C3-IN-13
  • HY-44824
    SMARCA2 ligand-13 2660235-29-8
    SMARCA2 ligand-13 is a PROTAC target protein ligand (Ligand for Target Protein for PROTAC). SMARCA2 ligand-13 can be used for synthesis PROTACs.
    SMARCA2 ligand-13
  • HY-173136
    KDM4 ligand-1
    KDM4 ligand-1 is a ligand for target protein (histone lysine demethylase KDM4) for PROTACs. KDM4 ligand-1 can be used in the synthesis of PROTACs (HY-173135).
    KDM4 ligand-1
  • HY-171893
    CRBN ligand-185
    CRBN ligand-185 is a CRBN ligand. CRBN ligand-185 can be used as a target protein ligand for the synthesis of PROTACs targeting CRBN (Ligands for Target Protein for PROTAC), such as NX-5948 (HY-153321).
    CRBN ligand-185
  • HY-184211
    BRD9 ligand-14 3126237-28-0
    BRD9 ligand-14 is a BRD9 ligand that acts as a protein-of-interest ligand for synthesis of BRD9 PROTAC degraders. BRD9 ligand-14 can be used for research in acute myeloid leukemia.
    BRD9 ligand-14
  • HY-183817
    GNE-781-COOH 2484742-13-2
    GNE-781-COOH is a CBP/p300 degrader. GNE-781-COOH also acts as a ligand for target protein for PROTAC (Ligands for Target Protein for PROTAC), which can be used to synthesize PROTAC CBP/P300 Degrader-4 (HY-183802).
    GNE-781-COOH
  • HY-181393
    EZH2 ligand-3 3034875-47-0
    EZH2 ligand-3, a EZH2 ligand, is a PROTAC target protein ligand (Ligand for Target Protein for PROTAC). EZH2 ligand-3 can be used for the synthesis of PROTAC EZH2 Degrader-35 (HY-181392).
    EZH2 ligand-3
  • HY-168056
    KRAS ligand 5 3043896-37-0
    KRAS ligand 5 is the target protein ligand for PROTAC K-Ras Degrader-3 (HY-168054). PROTAC K-Ras Degrader-3 can specifically degrade KRAS mutated proteins.
    KRAS ligand 5
  • HY-171442
    PIN1 ligand-2 2957895-02-0
    PIN1 ligand-2 (Intermediate M6) is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). PIN1 ligand-2 can be used for synthesizing PROTACT (Rac)-P1D-34 (HY-171334).
    PIN1 ligand-2
  • HY-P11494
    AWWNTEW
    AWWNTEW (CP29) is a FOXM1-DBD peptide ligand with cytotoxicity to cancer cells. AWWNTEW has a strong affinity and binds to the FOXM1 protein. AWWNTEW is a component of FPP29 (HY-P11228). X
    AWWNTEW
  • HY-134497
    Rimonabant carboxylic acid 162758-35-2 99.91%
    Rimonabant carboxylic acid is a Ligand for Target Protein for PROTAC. Rimonabant carboxylic acid can be used to synthesize PROTAC CB1R Degrader-1 (HY-178176).
    Rimonabant carboxylic acid
  • HY-170339
    ER ligand-5 2421262-07-7
    ER ligand-5 is the ligand for estrogen receptor, that can be used as ligand for target protein for PROTAC synthesis of PROTAC ERα Degrader-10 (HY-170336).
    ER ligand-5
  • HY-175886
    FTO ligand-1
    FTO ligand-1 is a FTO ligand for FTO PROTAC degrader FP54 (HY-175885). FTO ligand-1 can inhibit cell proliferation and block the FP54-induced FTO degradation. FTO ligand-1 can be used for research of cancer, such as acute myeloid leukemia (AML).
    FTO ligand-1
  • HY-183800
    JH-l-25-NH2
    JH-l-25-NH2 is an IRAK1/4 inhibitor analog derived from JH-I-25 and serves as the IRAK4-binding moiety for synthesizing VHL-recruiting and CRBN-recruiting IRAK4 PROTAC degraders.
    JH-l-25-NH2
  • HY-111849
    Imatinib carbaldehyde 1436868-85-7
    Imatinib carbaldehyde (CGP-57148B carbaldehyde), the Imatinib (ABL inhibitor) based moiety, binds to IAP ligand via a linker to form SNIPER.
    Imatinib carbaldehyde
  • HY-176429
    MNK1 ligand 1 1578413-29-2
    MNK1 ligand 1 (Compound 5) is a MNK1 ligand. MNK1 ligand 1 can be used for synthesis of PROTAC MNK1 degrader-1 (HY-176428).
    MNK1 ligand 1
  • HY-174475
    ER ligand-11
    ER ligand-11 is the ligand for ERα and can be used for synthesis of PROTACs, such as PROTAC ERα Degrader-12 (HY-174453).
    ER ligand-11
  • HY-182017
    ATR ligand 2 3060178-60-8
    ATR ligand 2 (Compound 26) is a ATR PROTAC ligand. ATR ligand 2 can be conjugated with E3 ligase Ligand (HY-W077589A) and linker to synthesize PROTAC ATR degrader-3 (HY-182016).
    ATR ligand 2
  • HY-170349
    SMARCA2 ligand-11 3033592-44-5
    SMARCA2 ligand-11 is the ligand for SMARCA2, and can be used for synthesis of PROTAC SMARCA2 degrader-32 (HY-170343) as ligand for target protein.
    SMARCA2 ligand-11